What dose-fractionation scheme and esophageal constraints should be used to treat an ultra-central, medically inoperable, stage I NSCLC abutting the esophagus?
Is there a safe regimen that still delivers BED >100?
Answer from: Radiation Oncologist at Academic Institution
For lesions abutting the esophagus, SBRT with BED >100 Gy should NOT be used due to high risk for ulceration and even fistula. Instead of SBRT, more fractionated radiotherapy with BED <84 Gy should be considered (60 Gy in 15 FX is still too high for the esophagus). In addition to maximal point...
Comments
Radiation Oncologist at Mon Health Thank you. Specifically, what fractionation scheme...
Radiation Oncologist at Mallory Radiotherapy, PLLC I typically treat with 63 Gy in 10 fractions (BED1...
Radiation Oncologist at Mon Health Thank you. I posed the question in the lung cancer...
Answer from: Radiation Oncologist at Community Practice
I prefer to prescribe 60/15 to the PTV with no more than 45/15 to the esophagus. Gated treatment targeting the GTV (instead of free-breathing targeting the iGTV) is strongly preferred for cases like this.
Comments
Radiation Oncologist at Brooke Army Medical Center Thank you for the many replies. I greatly apprecia...
Radiation Oncologist at Montefiore Einstein Comprehensive Cancer Center "Reduce the dose delivered to the GTV in the regio...
Radiation Oncologist at Mallory Radiotherapy, PLLC It's a really interesting discussion. I guess the ...
Thank you. Specifically, what fractionation scheme...
I typically treat with 63 Gy in 10 fractions (BED1...
Thank you. I posed the question in the lung cancer...