What factors would make you strongly consider re-irradiation of the chest wall in a patient who has previously undergone whole breast irradiation?   

For an in-breast tumor recurrence (IBTR) after BCS and breast (only) radiotherapy (assuming the patient undergoes mastectomy) I would offer re-irradiation for any indications I normally would for PMRT (node positivity, involvement of the skin, inflammatory recurrence, etc). It should be noted that w...