What heart dose constraint should be used when treating locally advanced NSCLC?

I use V50 <25%, then again I was the senior author on one of those 3 papers, so I'm a bit biased!

To be clear, though, I think the punchline here is that the metric being use is fundamentally less important than just using a metric that is more stringent than the historic constraints.

It is well est...

Based on pooled data from UNC dose-escalation trials have been using a mean heart dose of <20Gy, as this correlated with <10% risk of cardiac event (with little difference between <10Gy and 10-20Gy, risk of cardiac events 4% versus 7%) while once mean heart dose exceeds 20Gy, the risk of cardiac eve...