What high risk features for stage IB NSCLC would lead you to consider adjuvant chemotherapy?

Do you consider size > 2cm, visceral pleural invasion or vascular invasion as indications for cisplatin-based chemotherapy?

Answer from: Medical Oncologist at Academic Institution

Short answer is "no", I would not change practice based on the recently presented (ASCO) a non-randomized analysis of the potential benefits of adjuvant chemotherapy for patients with stage I NSCLC in Japan (Tsutani, et al. JCO 37(15S):457s, 2019; abst 8500). Many of these patients received UFT rath...

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Medical Oncologist at IHA Hematology Oncology Consultants - Ann Arbor
I have a follow up question- In a patient with St...

Medical Oncologist at University of Michigan Medical School
The ADAURA trial included patients with stage IB d...

Answer from: Medical Oncologist at Academic Institution

High risk features in stage IB NSCLC would include presence of lymphovascular invasion, poor differentiation, or high standardized uptake value (SUV) on positron emission tomography (PET; variably defined as SUV 10 or more. I don't think size of 2cm has been an accepted high risk features. Tumor siz...

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Medical Oncologist at Siri Onclogy and hematology Infusion Service
A very appropriate answer. However, I would like t...

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What high risk features for stage IB NSCLC would lead you to consider adjuvant chemotherapy?

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