What is the age cut-off to omit radiation therapy after breast conserving surgery for early stage breast cancer?
The Hughes study looked at women > 70 years of age. In light of the PRIME II results, can women aged 65 - 70 avoid RT or is longer follow up needed?
Answer from: Radiation Oncologist at Academic Institution
I agree with the above answers and would like to expand a bit. What is so special about being over 70 (or over 65 for that matter) when your breast cancer is diagnosed? Not much. Age is a rough surrogate for life expentancy and perhaps also for biologic subtype. But we have SEVERAL trials across bro...
Answer from: Radiation Oncologist at Academic Institution
The results of the Hughes CALGB 9343 study and the more recent PRIME II data certainly support a discussion and consideration of omission of radiation in the 65-70 year old or above patient population. However, since the long term results from the Hughes study shows a somewhat high absolute risk of ...
Answer from: Radiation Oncologist at Community Practice
I think all previous studies have clubbed all ER positive breast cancer together, but going forward the phenotype of tumor would be most important in deciding about RT since data suggesting luminal A type probably have the least benefit. There are ongoing randomised studies looking at omitting...