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What is the clinical significance of a low titer RNP, negative Sm, but Sm/RNP that is very high titer?
I'm uncertain why both individual parts can be so low/negative but together very positive. Is there an assay discrepancy, a false positive?
Answer from: at Community Practice
Important question as I've seen clinicians incorrectly interpret anti-Sm-RNP as anti-Smith antibody.
The different autoantibodies (RNP, Smith, Sm/RNP) react to different antigens as follows:
Anti-RNP can react to multiple components (antigens) of the U1 small nuclear RNP particle (snRNP)
Anti-Smi...
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