What is the clinical significance of a low titer RNP, negative Sm, but Sm/RNP that is very high titer?

I'm uncertain why both individual parts can be so low/negative but together very positive. Is there an assay discrepancy, a false positive?

Answer from: at Community Practice

Important question as I've seen clinicians incorrectly interpret anti-Sm-RNP as anti-Smith antibody.The different autoantibodies (RNP, Smith, Sm/RNP) react to different antigens as follows: Anti-RNP can react to multiple components (antigens) of the U1 small nuclear RNP particle (snRNP), Anti-Smit...

Comments

at Hill Country Dermatology
Thank you for your above response to a question th...

at Austin Regional Clinic
Thank you for the very informative and helpful ans...

at Uniformed Services University of the Health Sciences (USUHS)
I agree with your dx and plan. Sounds like untreat...

at University of Nevada - Las Vegas
Excellent and informative discussion trail. Re: s...

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What is the clinical significance of a low titer RNP, negative Sm, but Sm/RNP that is very high titer?

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