What is the optimal adjuvant vaginal brachytherapy schedule when a patient is getting concurrent chemotherapy?
Is there any evidence that variation in schedule (once weekly vs. every other day in between cycles) can affect outcome? Does this vary with dose prescription (i.e. 30 Gy to surface versus 21 Gy to 5mm depth)?
Answer from: Radiation Oncologist at Community Practice
I treat in the two weeks between cycles once adequately healed from surgery. Often this is between cycles 1-2 but occasionally between 2-3. I don’t modify my prescription.
Answer from: Radiation Oncologist at Academic Institution
I offer 7 Gy x 3 weekly, but prefer 6 Gy x 5 to surface regardless of when chemotherapy is given.
We have some currently unpublished, but upcoming institutional research submitted to ABS 2025 that showed increased risks of vaginal stenosis with 21 Gy in 3 fx to depth compared to a more gentle fract...