What is the optimal treatment strategy for patients with stage IV NSCLC who have an actionable molecular target identified after initiation of first-line systemic therapy?  

I am assuming that immune checkpoint inhibitors were held while molecular results were pending based on evolving literature in the field (Calles et al., PMID 32421452). My personal recommendation is to complete 2-4 cycles of platinum doublet chemotherapy and obtain repeat imaging after completing th...