What is the preferred agent for metastatic male breast cancer patient who progresses on tamoxifen and is not a candidate for chemotherapy?  

This is luckily not a common scenario. Metastatic breast cancer in men is quite unusual in a typical practice, primarily because the disease is rare to begin with and we would most often see men with non-metastatic disease.Of course, the majority of breast cancers in men are ER-positive, more than w...

For endocrine therapies for metastatic breast cancer in men, after initial response to tamoxifen and then progression, as in premenopausal women, treatment should include suppression of gonadal function. When there is no response to first-line endocrine therapy with tamoxifen, the chance of respons...