What is your approach for using anticoagulation/aspirin in patients with multiple myeloma?  

Excellent question with lots of nuances but no clear answer. I'll start with my gestalt approach, which is to consider a DOAC for every patient with myeloma if all of the following are true: They are receiving an IMiD (lenalidomide or pomalidomide) They set off my 'spidey sense' with one or more o...

@Rahul Banerjee has done a wonderful job here.  My practice is to start a prophylactic dose DOAC (apixaban 2.5 mg BID, rivaroxaban 10 mg daily) for essentially all patients with newly diagnosed myeloma. This is in part because we frequently employ quadruplets and/or cafilzomib-based regimens. ...