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What is your approach to a patient with muscle invasive bladder cancer getting neoadjuvant gemcitabine/cisplatin who develops significant ototoxicity due to cisplatin after two cycles?
Had mild baseline tinnitus, now with significant worsening, and decreased hearing.
Answer from: Medical Oncologist at Community Practice
My approach would be to proceed to surgery and based on pathological response, determine if the patient is a candidate for nivolumab.For patients who cannot tolerate cisplatin, there is no recommendation for an alternate regimen in the neoadjuvant setting.If treatment-naive and cisplatin-ineligible ...
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