What is your approach to mitigating the infection risk with bispecific antibodies in multiple myeloma?

As of June 2023, anybody who says they have a definite answer to this is misleading you. We are unfortunately learning as we go, and LOTS of loose ends to be tied up. I'd argue everybody in this setting should already be on universal VZV prophylaxis (e.g., acyclovir), and I'd also argue that most of...

• VZV/PJP prophylaxis
• IVIg q 4 weeks for hypogammaglobulinemia
• PEG-GCSF support for neutropenia
• If the patient has response plateau for 2 consecutive cycles, then move to q 2-week dosing or even q 4-week dosing sooner than later. I am doing this in clinical practice as early as cycle 3 or 4. Check ou...

I agree with Dr. @Dr. First Last. PCP prophylaxis may need to be considered.

I agree with Dr. @Dr. First Last. VZV, PJP prophylaxis and consider levofloxacin for a short period (usually first month). Quantitative immunoglobulins should be closely followed. Monitoring serum CMV PCR may lead to over-treatment if the patient just has CMV viremia and not an actual CMV infection,...