What is your approach to patients with severe infusion reaction but excellent response to checkpoint inhibitors?  

In patients with very severe infusions reactions, ie anaphylaxis, I would discontinue the checkpoint inhibitor, as it is very likely that the response will persist after discontinuation of the therapy.  This is the type of patient that I would favor a treatment holiday with close interval ...

I agree with @Liza C. Villaruz about stopping checkpoint inhibitors if it is severe anaphylactic reaction.If it is grade 3 or less, I would slow down infusion to 50% and give premedications acetaminophen, ranitidine, and diphenhydramine. If reaction is higher grade, would also add steroids. Aft...

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