What is your current practice for obtaining mutation status for a patient with newly diagnosed ovarian cancer?
What specific platforms for determining somatic BRCA and HRD status do you use for a patient who does not carry a germline BRCA mutation?
Answer from: at Community Practice
My current practice is to test all newly diagnosed epithelial ovarian cancer patients (includes fallopian tube and peritoneal) with both germline multigene and somatic multigene/NGS panels. Only recently have I adopted the practice of concurrent testing at diagnosis rather than basing the decision t...
Comments
Medical Oncologist at Texas Oncology A very good review incorporating the testing basic...
Medical Oncologist at Arizona Hem/Onc Excellent review for practicing oncologists. Great...
Currently, patients with newly diagnosed epithelial ovarian cancer undergo germline genetic testing using the Myriad MyRisk platform. This allows for integrated reflex testing with Myriad MyChoice (in the context of negative gremline BRCA testing), capturing somatic BRCA, as well as HRD status. In p...
Answer from: Medical Oncologist at Academic Institution
All ovarian patients at our center get referred for comprehensive genetic testing (to look for germline mutations). Some of these platforms will reflex negative germline testing to somatic testing.
If that is not done in a particular case, then we will send tissue for Myriad MyChoice testing to obt...
A very good review incorporating the testing basic...
Excellent review for practicing oncologists. Great...