What is your plasma oxalate target when treating patients with lumasiran for end stage kidney disease secondary to primary hyperoxaluria type 1?  

We have a lot of experience with the PH1 population on dialysis here using the Mayo Clinic Laboratory Plasma oxalate assay. Ideally, we shoot for a pre-dialysis value of 30 or less. In our experience with this and other Hyperoxaluric patients, the risk of oxalosis would be low at those numbers and a...