What is your preferred first line therapy in well differentiated GI NET with Ki67 > 55%?  

Without much detail provided here, I think understanding the biological behavior of this tumor is a key detail. For more indolent biology, you can use everolimus or SSA therapy, for example. For more aggressive disease, you would lean toward cape/tem, etoposide/platinum, or FOLFOX. An excellent trea...

NET with > 55% Ki-67 is more likely to behave like a poorly differentiated tumor/NEC. This can be further confirmed by lack of DOTATATE uptake, avid FDG uptake, and mutations such as p53 and Rb. ATRX/DAXX and MEN1 will mean a grade 3 well differentiated, in which case capecitabine/temozolomide wi...