What is your preferred salvage chemotherapy regimen for bridge to auto SCT for patients with relapsed classical Hodgkin Lymphoma?

There are multiple regimens including IGEV and most recently reported results of BEGEV without preference on NCCN guidelines.

Answer from: Medical Oncologist at Academic Institution

We actually have been favoring using a bendamustine-brentuximab based regimen (in those who have not received brentuximab in the front line setting). Supportive data is based on Lancet Oncol. Feb 2018 that showed a favorable toxicity profile with an almost 80% ORR. Usually will give 2-3 cycles,...

Comments

Medical Oncologist at Northwest Georgia Oncology Centers
The obvious follow up question would be the regime...

Medical Oncologist at The Ohio State University Comprehensive Cancer Center / James Cancer Hospital and Solove Research Institute
I wouldn't use brentuximab up front unless there w...

Answer from: Medical Oncologist at Academic Institution

Honestly, the most important point is to achieve CMR on PET/CT before AutoSCT, rather than how to achieve it. Brentuximab vedotin-based regimens (if not received in 1L treatment) are mostly used as single agent or in addition to bendamustine.

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What is your preferred salvage chemotherapy regimen for bridge to auto SCT for patients with relapsed classical Hodgkin Lymphoma?

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