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Breast Cancer • Medical Oncology • NCI-CCC Tumor Board Question • Her2+ • University of Wisconsin • HR+ • NCI-CCC Breast Tumor Board Question
What is your strategy for a patient who develops an enlarging ipsilateral axillary lymph node shortly after undergoing mastectomy and ALND for a pT2N3 ER+/HER2+ right breast cancer?
This patient underwent mastectomy and ALND (10/28 positive lymph nodes). Immediately following axillary LN dissection (and prior to radiation) imaging was concerning for an enlarged ipsilateral axillary LN.
Answer from: Medical Oncologist at Academic Institution
Assuming this patient had neoadjuvant chemo and HER2 targeted therapy and has been on trastuzumab and pertuzumab per standard of care when this node grew (also assuming this node has been biopsied and confirmed to represent progressive ER+/HER2+ disease), this represents biologically aggressive dise...
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