What neoadjuvant regimen would you consider using for a healthy patient with node positive TNBC who is refusing anthracycline?  

In a patient with node-positive TNBC not eligible for an anthracycline, or refusing an anthracycline, I would strongly consider proceeding with a platinum + taxane + pembrolizumab, mirroring the NeoPACT trial presented by @Priyanka Sharma at ASCO 2022, which is the same regimen of carboplatin/doceta...

For node positive TNBC patients who are not eligible for anthracycline, or who refuse anthracycline, I would use 6 cycles of TC per the West German Plan B trial (Nitz et al., PMID 30785826). This study randomized patients with high-risk localized breast cancer to epirubicin/cyclophosphamide x 4 foll...