What recommendations do you make regarding the use of biologics for uncontrolled Crohn's disease in patient's who have a history of DLBCL that developed while on infliximab and azathioprine and whose lymphoma is essentially cured?  

This is a frequent question without a clear answer. There has not been a randomized study of anti-auto-immune therapy strategies to define the risk of a relapse or secondary lymphoma in patients with a clear need for treatment.  I recommend the patient work with their rheumatologist to start a...