What would your management approach be for a patient with high grade large cell neuroendocrine of the lung, status post resection with negative margins, but visceral pleura invasion noted on path?

Would adjuvant chemotherapy suffice, or would you also consider RT in a patient with a PS of 0-1? Would your recommendations change if it was N0 vs N1?

Answer from: Radiation Oncologist at Academic Institution

At present, the role of post-operative radiotherapy (PORT) has been shown, but not definitely proven to be detrimental for patients with resected NSCLC with N0 and N1 involvement by retrospective reviews of the ANITA trial and the SEER database (Lally et al J Clin Oncol 2006; 24:2998-3006), as well ...

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What would your management approach be for a patient with high grade large cell neuroendocrine of the lung, status post resection with negative margins, but visceral pleura invasion noted on path?

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