When do you consider employing the 4-week dosing schedule for nivolumab?  

I am beginning to see harsher toxicities while using 480 every 28 days so I have begun to revert back in those pts to 3 mg/kg every two weeks to be able to continue. So far so good but sample size too small.  I am wondering whether others have opinions about this.  Would be a precedent for...

Thanks for all this helpful information. Some pts of course tolerate Nivo 480 mg q 28 hrs just fine, while indeed I have seen more toxicity with this dosing scheme. Yet, also, I am seeing so much clinical activity that I do wonder whether there is a dose response despite notions to the contrary. All...

I use it as studied.  That is to say, that if I have a patient with good response to Q2W nivo, I'm open to switching to Q4w to improve patient convenience.  I don't start patients at Q4w nivo.

Now some clinical data to support the PK data on q4 week dosing. The final analysis is pending but preliminary results were recently reported on CheckMate 384, a phase IIIb/IV study comparing nivolumab 240mg q2 weeks vs. 480mg q4 weeks for patients with advanced NSCLC. Prelim results showed that tre...

I usually don't consider the 4 week schedule. I have used it in less than 5% of my patients.