Please select the option that best describes you:
Topics:
Neurology • Movement disorders
When do you consider testing for anti-IgLON5 disease in patients with parkinsonism?
Answer from: at Community Practice
Anti-IgLON5 disease is a rare and intriguing entity with an expanding phenotype. It has features of both autoimmune (antibody against a cell adhesion molecule, response to immunotherapy in some cases) and neurodegenerative (tau deposition, gradual course) disorders. Unlike many other autoimmune pres...
Sign in or Register to read more
Answer from: at Community Practice
I agree with the answer. In general, it is not very common to see parkinsonism as an isolated manifestation of anti-IGLON5. If I see a patient with parkinsonism, the clinical features that would make me think of anti-IGLON5 are new onset sleep-related problems that extend beyond just RBD, dysphagia ...