When do you feel comfortable adding bevacizumab to a BRAF-WT, KRAS-mutated colon cancer patient with previously hemorrhagic brain mets that responded to radiation?

It should be safe to add bevacizumab at this time. Radiation will reduce vascularity after 4-6 weeks. The incidence of bleeding with Bev (in the absence of anticoagulation) is quite low. Actually lower than the risk of thrombosis or wound healing complications. Go for it.

Completely agree with Dr. @Dr. First Last.

Colorectal cancer patients with brain metastatic disease are rare (a recent systemic review reported incidence of about 2.1%) (Müller et al., PMID 33669974) so data for this specific population is limited. However, there is a recent meta-analysis of bevaciz...