When using active surveillance for rising PSA after prostatectomy, at what level of PSA would you start ADT?  

Given the EMBARK data (Freedland et al., PMID 37851874), I would typically treat with ADT + enzalutamide if the PSA level was between 2.0 and 5.0 ng/mL following maximal definitive local therapy (RP + adjuvant/salvage RT). This would apply only to patients with a PSADT of <9 months. For those wit...

I agree with many caveats. The PSA level of 10 is quite arbitrary and in older studies from Hopkins, the median PSA at the time of metastases using conventional CT/bone scan imaging is around 30, and of course, is much lower with Axumin/PSMA PET imaging. However, this does not mean that earlier use ...

I don’t think I understand the question. Is it asking about ADT monotherapy or ADT type and duration in addition to radiation? If I have a patient with a rising PSA after prostatectomy, I’m going to treat them with radiation assuming they are not metastatic. If the question is asking abo...