When using conventionally fractionated breast RT, does one need to treat the whole breast to 50Gy or is 45Gy, followed by a boost satisfactory?

One of the reasons why hypofractionation schedule appears to have less acute and late morbidity in comparison to 50 Gy is because of lower equivalent total dose ( about 46 Gy equivalence). Besides the data is mostly on central axis dose homogeneity rather than 3D dose homogeneity and for that reason...