Which chemotherapy is preferred between TC and AC-T in a young patient with ER+/PR+/HER2- node negative breast cancer, intermediate grade, with high OncoType score?   

If this patient has a small, node negative, hormone receptor positive, HER2 negative intermediate grade tumor, I would be comfortable with recommending 4 cycles of adjuvant docetaxel and cyclophosphamide. Based on ABC trial results, the groups that benefited from AC-T regimen were patients with high...

For a node negative HR+ HER2- tumor in a pre-menopausal patient, I will usually recommend TC although I do discuss AC-T as well. This is based on the results of the ABC trial. Subset analysis of ABC suggested that the benefit for anthracyclines is largely derived by patients with triple negative can...

In the ABC analysis, patients with node-negative, ER+/HER2- cancers (Blum et al., PMID 28398846) actually did worse when they received an anthracycline in addition to TC (HR 0.69 for TC vs. TaxAC).