With the intent for cure, what neoadjuvant therapy would you give a patient with only chest wall recurrence 10 years after an advanced breast cancer was managed with mastectomy, ddAC and T, and 5 years of adjuvant endocrine therapy?  

A chest wall recurrence is associated with high risk of metastatic disease either at time of diagnosis of the chest wall recurrence or over the next 5 years. Women who develop chest wall recurrences should be restaged. The approach to an isolated chest wall recurrence in this case is surgery with cl...