Would you be comfortable starting tamoxifen for a HR+ breast cancer patient with a history of early stage endometrial cancer treated via hysterectomy?  

I would have no problem putting someone with early endometrial cancer on tamoxifen who had had prior hysterectomy. There is no evidence that tamoxifen would increase the risk of recurrence of the endometrial cancer. In fact, recurrent endometrial cancer is sometimes treated with a combination of tam...