Would you combine sutimlimab with bendamustine rituximab for cold agglutinin disease if patient continues to hemolyze during treatment?  

In my experience, virtually all patients with true cold agglutinin disease respond to sutimlimab quite quickly. While there may be sub-clinical evidence of hemolysis for some time, generally hemoglobin improves to normal or close to this. Adding therapy to sutimlimab really depends upon the clinical...