Would you consider combination belimumab and anakinra for a patient who has SLE and MAS?  

I have used the combination of belimumab and IL-1 inhibition in a patient with SLE to treat recurrent pericarditis. It would not be unreasonable to use anakinra for MAS and add this to their belimumab. Managing MAS requires treatment of the underlying driver of the MAS, which in this case seems to b...

Would use anakinra in a patient on belimumab to help resolve MAS not resolving with escalated therapy for severe lupus flare, but initiating belimumab for this specific circumstance is not likely to be of any benefit in resolving the MAS because the clinical effects are not seen for several months. ...