Would you consider enfortumab vedotin + pembrolizumab prior to surgery for a patient with urothelial carcinoma with regional nodes who is not eligible for neoadjuvant cisplatin?

The appropriate management for LN+ bladder cancer is not clear, and whether or not to use EV+pembrolizumab in this setting is also without significant data. Clinically and practically, there are so many gray areas in this question that the best path is at best charcoal-colored. Generally, systemic t...

We actually have a trial open for these patients! EV-ECLIPSE - multicenter trial coordinated from MSKCC and open at UTSW in Dallas -- we are looking to fill out the cohort and learn from these patients! Absolutely think there is activity for EV-pembro not only in the LNs but also in the primary tumo...