Would you consider radiotherapy for unresectable malignant pleural mesothelioma in an asymptomatic patient?

In a non-surgical candidate, would you consider adding radiotherapy sequenced with chemotherapy at any point? Or do you reserve it for palliative purposes only?

If so, what volume and dose? NCCN guidelines say to consider RT for Stage I-IIIA disease, but do not give further guidance.

Answer from: Radiation Oncologist at Academic Institution

The standard of care is palliative chemotherapy + potential Ipi/Nivo now that there is that option. Radiation should be reserved for consolidation or palliation for symptomatic sites of disease or progression. Radiation should be done using hypofractionated approach, with dose per fraction exceeding...

Comments

Radiation Oncologist at Toledo Clinic Inc.
Thank you

Radiation Oncologist at Vanderbilt-Ingram Cancer Center
Dr. @Lin, can you provide the rationale for RT bei...

Radiation Oncologist at University of Texas MD Anderson Cancer Center
Hi Dr. @Shinde, there are quite a bit of advantage...

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Would you consider radiotherapy for unresectable malignant pleural mesothelioma in an asymptomatic patient?

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