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Thoracic Malignancies • Medical Oncology
Would you consider stopping EGFR inhibitor in EGFR mutant NSCLC on a patient who was NED for >5 years?
A female in her 60s who has been on afatinib for 6 years. Has been NED on CT, PET, and MRI for > 5 years. Had isolated T-spine mets (radiated) and primary right hilar mass that have all resolved.
Answer from: Medical Oncologist at Academic Institution
It's a great question! My bias would be to lean toward continuation in the absence of significant impact on QOL. Some literature is available describing the experience of long-term responders, but even then, the definition of long-term responders is up about 2-3 years, so well below the duration of ...
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