Would you deliver SRS/XRT for isolated asymptomatic CNS metastasis before start of immunotherapy for stage IV lung cancer (negative for driver mutation) with high positive PDL1?   

Good question. To my knowledge, we still do not have large prospective studies of combination SRS and ICI in NSCLC, but we do have several retrospective studies. Overall, patients with brain metastases from NSCLC treated with ICI seem to do better than we would expect for patients treated with chemo...