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Would you ever start radiation in the middle of cycle 1 of chemotherapy for LS-SCLC?
Or would you wait to start coincident with the start of cycle 2? If a shorter time from the start of any therapy to the end of radiation (SER) is significantly associated with improved survival, would it make sense to start radiation as soon as a plan is ready even if it is a few days or a week after starting cycle 1?
Answer from: Radiation Oncologist at Academic Institution
The goal is to get RT started early in the course, and to maximize the concurrent part of the therapy. But of course a patient only gets chemo for a few days per cycle, and we don't know whether the ‘concurrent’ effect is entirely due to those days treatment, or whether the ra...
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Answer from: Medical Oncologist at Academic Institution
Answer to question is Yes! A randomized phase III trial from Korea by Sun et al showed that thoracic radiation on cycle 3 of chemotherapy was not inferior to early radiation based on OS, PFS and RR.
https://academic.oup.com/annonc/article/24/8/2088/196699
Comments
Radiation Oncologist at Yale School of Medicine
Thanks @Grace K. Dy! How important is it to start ...
Thanks @Grace K. Dy! How important is it to start ...
Radiation Oncologist at UCLA | VA Greater Los Angeles Healthcare System
So, the benefits of chemosensitization - if that a...
So, the benefits of chemosensitization - if that a...