Would you favor treating HES manifesting with EoE with dupilumab or anti-IL5 therapy?  

That depends, and I'd need more information. Is this someone who has elevated peripheral eos and their GI tract is the only organ system involved (sometimes called 'overlap HES')? In this case, I'd ask GI colleagues to perform a colonoscopy as well to look for a lower EGID. I'd also screen for paras...