Would you feel comfortable giving a HER2+ breast cancer patient her next cycle of TCHP (Taxotere + carboplatin + Herceptin + Perjeta) on day 17 of the previous cycle?

No. I usually delay chemo but never give chemo a week prior to the scheduled time. I can try a day prior. I'm worried about unnecessary toxicity in such a setting. Remember, adjuvant or neoadjuvant therapy is given to optimize the cure. You don't want to create lasting toxicity or place a patient at...