Would you offer capecitabine re-challenge for a patient with metastatic breast cancer and a history of coronary vasospasm?  

Doing a 5FU/capecitabine rechallenge after vasospasm can be risky and fatalities have been reported. Capecitabine and infusion 5FU are riskier than bolus 5FU due to prolonged exposure of the endothelium to metabolites. In the US, we lack access to safer alternatives like S1. There are some reports o...