Would you offer chemotherapy to a patient with an in-breast recurrence less than 2 years after a history of lymph node positive ER+PR+HER2- breast cancer treated with mastectomy and adjuvant hormonal blockade?  

To clarify things, do you mean chest wall recurrence post-mastectomy, a in-breast recurrence in a nipple sparing mastectomy, or a new primary in the contralateral breast? First, with each of above scenarios it is a good idea to re-stage the patient. Secondly, given the two-year disease-free interval...