Would you offer chemotherapy to an elderly patient with MSI-H stage 3 colon cancer who cannot tolerate oxaliplatin?  

The current NCCN guidelines suggest CAPOX or FOLFOX (3-6 months) as preferred regimens for resected dMMR stage III colon cancer, while still listing single-agent fluoropyrimidine as an option. However, recent studies have indicated that adjuvant chemotherapy, particularly oxaliplatin, is necessary f...