Would you offer consolidation RT to a young woman with bulky mediastinal DLBCL who achieved early and persistent CR to RCHOP on PET?  

Dr. @Christopher R. Kelsey has modestly omitted one salient trial in his answer, namely the Duke trial which he led evaluating low dose consolidation RT (20 Gy) following CR to induction chemotherapy, i.e. PET negative response (Kelsey et al., PMID 30858144). To recapitulate briefly, 62 patients wit...

I would like to know a bit more about the extent of the disease, the number of cycles of R-CHOP delivered, and when CR was achieved.Assuming that this patient had an early stage (I-II) DLBCL with the only risk factor being "bulky disease" and achieved CR in the PET during chemotherapy (interim) and ...