Would you offer RT for a nodal recurrence of NSCLC that has resolved radiographically after chemotherapy?  

Nodal recurrences are bad. When addressing nodal disease that "disappears" after chemotherapy, I have modeled my decision making on the premise used in small cell lung cancer treatment where even in the face of CRs on imaging after chemotherapy, radiotherapy was always added to the mediastinal (noda...

If treating regional nodal recurrence of NSCLC (e.g., after surgery) with no prior radiotherapy, I would extrapolate from LA-NSCLC trials and recommend upfront concurrent chemoradiotherapy rather than sequential chemoradiotherapy. I would also extrapolate from PACIFIC and consider adjuvant durvaluma...