Would you offer treatment for asymptomatic CLL with WBC of ~300k or greater, high risk cytogenetics, or doubling time of 6-12 months?

Generally, starting treatment in a CLL patient is recommended based on the iwCLL criteria (Hallek et al., PMID 29540348).

There is no WBC threshold that would require to treat, but the vast majority of patients with a WBC of 300K will have other reasons to start therapy. If this would be a patient wi...