Would you proceed with anti-CD20 treatment in an MS patient who is VZV IgG negative in spite of vaccination in the last year?
Is this consistent with VZV immunity that is just seronegative on lab testing?
Answer from: at Academic Institution
There is no clear data on management. In my experience, if a patient has been vaccinated in the recent past, then I will proceed with anti-CD20 therapy. However, if vaccination was in the remote past, I have asked patients to repeat vaccination before initiating therapy.