Would you pursue temporal artery biopsy in patients with PMR who develop cranial GCA symptoms and have been on PMR dose steroids for one year?  

This is a challenging question. While the literature would suggest that the rate of positive biopsies after 14 days of prednisone have similar positivity to those done before 14 days (Achkar et al., PMID 8185147, retrospective study with potential for bias), there is no data to my knowledge regardin...