Would you recommend PMRT to a clinically node positive (biopsy proven axillary node and indeterminate single IMN node) BRCA positive patient with multiple medical co-morbidities including scleroderma and ILD who is treated with neoadjuvant chemotherapy (NAC) and mastectomy who converts to ypT0/ypN0?

Answer from: Radiation Oncologist at Community Practice

Given pathological complete response and comorbidities, I would favor the omission of RT. While not a clear B-51 case, if you think IM was involved, given the totality of the situation omission is how I would go as long as post-chemo MRI showed stable or smaller IM node.

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Radiation Oncologist at Northside Hospital
I would consider a PET to assess the status of the...

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