Would you recommend surgery or radiation for newly diagnosed localized prostate cancer diagnosed on a urethral lesion biopsy?  

I think the underlying question here is whether its urethral location changes the recommendations we would otherwise make, and really it doesn't. Let's talk it through: I don't feel that the urethral location affects my ability to treat this with EBRT as the urethra gets the same (curative) dose as ...

While most prostate cancer is distributed in the periphery of the gland, I think urethral involvement is much more frequent than might be appreciated by classical staging methods alone. This area is not well sampled with conventional systematic biopsy methods and patients may not always undergo MRI ...