Would you routinely offer IMRT to the entire pleural cavity in patients who undergo pleurectomy/local resection for mesothelioma without EPP?  

I do not, and wouldn't recommend, routine IMRT to the entire pleural space in patients with mesothelioma s/p pleurectomy/decortication outside of a clinical trial. If we have learned anything from this disease, it is that "less" is often "more". About 15 years ago there was a surge of interest in ag...