Would you use a hippocampal sparing technique when treating with PCI for a limited stage small cell lung cancer?  

This is an important question where the evidence is evolving, and some key trials remain ongoing. Because the data remains in flux, in the ongoing phase 3 SWOG S1827/Maverick trial of MRI surveillance +/- prophylactic cranial irradiation (PCI) for LS and ES-SCLC, where I serve as the PI, hippocampal...

The potential cognitive preservation benefits of hippocampal sparing remain the subject of ongoing phase III trials.  In the setting of PCI for small cell lung cancer, NRG CC003 is a phase III trial of PCI with or without hippocampal avoidance; at our institution, eligible patients are enrolled...